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Responsiveness of children with celiac disease to different hepatitis B vaccination protocols
Necati Balamtekın1, Nuray Uslu, Gökhan Baysoy
1Department of Pediatrics, Section of Gastroenterology, Hacettepe University School of Medicine, Ankara.
Insights
Children with celiac disease show lower hepatitis B vaccine response rates compared to healthy children. However, two different vaccination schedules did not significantly alter response rates in celiac patients.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Vaccinology
Background:
- Celiac disease may impact immune responses.
- Hepatitis B vaccination is crucial for infants.
- Understanding vaccine efficacy in celiac disease is important.
Purpose of the Study:
- To compare hepatitis B virus (HBV) vaccine response rates in children with celiac disease.
- To evaluate two different infant immunization schedules for HBV vaccine.
- To assess if vaccination protocols affect HBV vaccine response in celiac patients.
Main Methods:
- Two study groups of celiac patients received HBV vaccine at different schedules (0, 2, 9-12 months vs. 0, 1, 6 months).
- Two control groups of healthy children followed the same schedules.
- Response rates were measured in the first year of life.
Main Results:
- Celiac patients exhibited lower overall HBV vaccine response rates (78.1%) compared to healthy controls (95.9%).
- No statistically significant difference in response rates was observed between the two vaccination schedules within the celiac patient groups.
Conclusions:
- The chosen hepatitis B vaccination schedules did not yield statistically different response rates in children with celiac disease.
- While celiac patients showed reduced response rates, the specific schedules evaluated did not impact this outcome.
- Further research may explore factors influencing vaccine response in pediatric celiac disease.
Background/Aims:
We aimed to compare the response rates to hepatitis B virus vaccination in the first year of life, using two different immunization protocols, in children with celiac disease.
Methods:
Study Group 1 included patients with celiac disease who received 10 μg of hepatitis B vaccine intramuscularly at birth (0), 2 and 9-12 months of life. Group 2 included those who received hepatitis B vaccine at 0, 1 and 6 months of life. Healthy children were divided into two control groups according to the above schedules.
Results:
The total study group included 64 patients and 49 healthy controls. Celiac patients were found to have lower response rates with respect to controls (78.1% vs. 95.9%, respectively). The difference in response rates in the two patient groups was not statistically significant.
Conclusions:
The response rates of celiac patients to the two different hepatitis B vaccination schedules showed no statistically significant difference.
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