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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Related Experiment Video

Updated: Jun 2, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Using the NCBI Map Viewer to browse genomic sequence data.

Tyra G Wolfsberg

    Current Protocols in Human Genetics
    |April 12, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This guide explains how to use the NCBI Map Viewer for genome exploration. Learn to search gene annotations, navigate chromosomes, and utilize BLAST and other tools for sequence analysis.

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    Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
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    Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

    Published on: May 9, 2011

    Area of Science:

    • Genomics
    • Bioinformatics

    Background:

    • The National Center for Biotechnology Information (NCBI) provides valuable tools for genomic research.
    • Effective navigation and querying of genome data are essential for biological discovery.

    Purpose of the Study:

    • To provide a user-friendly protocol for navigating and analyzing genomic data using the NCBI Map Viewer.
    • To introduce various methods for querying genome sequences and annotations.

    Main Methods:

    • Utilizing the NCBI Map Viewer for text-based searches of gene annotations.
    • Navigating along chromosomes, zooming, and customizing map displays.
    • Performing Basic Local Alignment Search Tool (BLAST) searches against the human genome.
    • Retrieving gene lists between Sequence Tagged Site (STS) markers.
    • Identifying annotated gene family members.

    Main Results:

    • Demonstrated basic functionalities of the Map Viewer for viewing genomic context.
    • Illustrated advanced querying techniques including BLAST, STS marker-based retrieval, and gene family identification.
    • Highlighted the integration of NCBI's sequence analysis tools within the Map Viewer.

    Conclusions:

    • The NCBI Map Viewer is a versatile tool for exploring and analyzing genomic information.
    • The described protocols enable researchers to efficiently query and understand genome sequences and annotations.