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Updated: Jun 2, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Genomic signatures of cancer: basis for individualized risk assessment, selective staging and therapy
Frederick L Baehner1, Mark Lee, Michael J Demeure
1Department of Anatomic Pathology, UCSF Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, California 94115, USA. rick.baehner@ucsf.edu
Abstract:
The development of DNA microarray and quantitative real-time polymerase chain reaction technologies has allowed for precise quantitation of RNA expression of hundreds to thousands of genes. These technologies have significantly impacted the study and understanding of cancer in terms of its molecular and genetic characteristics. In this review article, breast cancer, colon cancer, and adrenal carcinoma have been chosen to illustrate the principle and techniques of genomic profiling and to illustrate how such methods may be used to develop genomic signatures for personalized risk assessment and to individualize patient treatment.
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