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Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
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Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis

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Amplified protein detection through visible plasmon shifts in gold nanocrystal solutions from bacteriophage platforms

Ju Hun Lee1, Jennifer N Cha

  • 1Department of Nanoengineering and Engineering Program, University of California, San Diego, La Jolla, 92093-0448, United States.

Analytical Chemistry
|April 13, 2011
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...