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Updated: Jun 2, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Pan-myeloid Differentiation of Human Cord Blood Derived CD34⁺ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

Towards responsible cord blood banking models.

P Rebulla¹, L Lecchi

¹Milano Cord Blood Bank, Centre of Transfusion Medicine, Cellular Therapy and Cryobiology, Department of Regenerative Medicine, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. prebulla@policlinico.mi.it

Cell Proliferation

|April 13, 2011

Summary

Global registries offer millions of hematopoietic stem cell donors and cord blood units. However, more effort is needed to ensure all patients, especially minorities, find timely matches.

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Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

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Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Pan-myeloid Differentiation of Human Cord Blood Derived CD34⁺ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Area of Science:

Hematology
Transplantation Immunology
Public Health

Background:

Over 14 million bone marrow/apheresis donors and 426,000 cord blood units were available globally by May 2010 for hematopoietic stem cell transplantation (HSCT).
Despite extensive donor registries, challenges persist in matching all patients, particularly those from ethnic minorities, with suitable hematopoietic stem cell (HSC) donors.
Existing models require enhancement to meet the diverse needs of all HSCT candidates.

Purpose of the Study:

To highlight the current state of global HSC and cord blood registries.
To emphasize the ongoing need for improved donor and cord blood unit accessibility for all patients.
To advocate for collaborative efforts in developing effective HSCT and cord blood banking strategies.

Main Methods:

Analysis of global bone marrow/apheresis donor and cord blood unit registry data as of May 2010.
Review of existing challenges in patient matching, including ethnic disparities.
Consideration of expert opinions and scientific evidence on cord blood banking models.

Main Results:

As of May 2010, 14,072,567 bone marrow/apheresis donors and 426,501 cord blood units were available across multiple countries.
Significant disparities remain in finding suitable donors for all patients, particularly ethnic minorities.
Expert consensus favors public, solidaristic cord blood donation over private, autologous storage.

Conclusions:

Continued global collaboration among governments, clinicians, scientists, and stakeholders is crucial for advancing HSCT and cord blood banking.
Solidaristic public cord blood donation is supported as the preferred model for equitable patient access.
Further development of donation and banking models is necessary to fully address all patient needs in HSCT.