Related Experiment Video

Updated: Jun 2, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

[Hyperglycaemia as bad prognostic factor in acute coronary syndrome]

J L Cabrerizo-García1, J A Gimeno-Orna, B Zalba-Etayo

  • 1Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. j cabrerizo@hotmail.com

Revista Clinica Espanola
|April 13, 2011
PubMed

Insights

Admission hyperglycemia (≥ 139 mg/dl) in acute coronary syndrome patients significantly increases the risk of death within six months. This elevated risk is independent of diabetes and other known risk factors.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Medicine

Context:

  • Hyperglycemia is a common finding in patients presenting with acute coronary syndrome (ACS).
  • Understanding the prognostic implications of admission hyperglycemia is crucial for risk stratification and management.
  • Previous studies have suggested a link, but independent prognostic value requires further investigation.

Purpose:

  • To analyze the relationship between admission hyperglycemia and mortality in patients with acute coronary syndrome (ACS).
  • To determine if hyperglycemia on admission is an independent predictor of short-term mortality after ACS.
  • To investigate the association between glycemia levels and other clinical, electrocardiographic, and echocardiographic variables.

Summary:

  • A prospective study of 455 high-risk ACS patients (with or without ST-segment elevation) was conducted.
  • Patients were stratified by admission glucose levels (< 139 mg/dl vs. ≥ 139 mg/dl).
  • Admission hyperglycemia (≥ 139 mg/dl) was independently associated with a significantly higher six-month mortality risk (HR=2.98, P=0.039).

Impact:

  • Admission hyperglycemia ≥ 139 mg/dl is a significant independent predictor of increased six-month mortality in ACS patients.
  • These findings highlight the importance of monitoring and managing blood glucose levels in ACS patients, even those without a prior diabetes diagnosis.
  • The results can inform clinical guidelines for risk assessment and therapeutic interventions in acute coronary syndromes.
Abstract

More Related Videos

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...