Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microcirculation in the hypertrophic and ischemic heart.

H Tillmanns1, F J Neumann, N Parekh

  • 1Abteilung Innere Medizin-Kardiologie, Medizinische Universitätsklinik, Giessen, FRG.

European Journal of Clinical Pharmacology
|January 1, 1990
PubMed
Summary

Hypertension-induced left ventricular hypertrophy (LVH) in rats shows reduced capillary density and impaired red blood cell recruitment, potentially explaining chest pain in patients with LVH and normal coronary arteries.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chlorine-induced dental pigmentation in a long-term swimmer.

British dental journal·2024
Same author

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

European geriatric medicine·2021
Same author

The role of asymptomatic screening in the detection of recurrent ovarian cancer.

Gynecologic oncology reports·2020
Same author

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Drugs & aging·2019
Same author

Birth weight, early life weight gain and age at menarche: a systematic review of longitudinal studies.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Increased risk and pattern of secondary malignancies in patients with invasive extramammary Paget disease.

The British journal of dermatology·2014

Area of Science:

  • Cardiovascular Physiology
  • Renal Hypertension Research

Background:

  • Myocardial hypertrophy, common in hypertensive heart disease, reduces coronary vascular reserve despite normal coronary arteries.
  • Functional microcirculatory changes precede structural alterations in hypertensive models.

Purpose of the Study:

  • To investigate microcirculatory changes in the left ventricular myocardium of rats with renal hypertension and pressure-induced left ventricular hypertrophy (LVH).
  • To assess capillary function and red blood cell recruitment under normoxic and hypoxic conditions.

Main Methods:

  • In vivo fluorescence microscopy and morphometric analysis were used in 10 rats with renal hypertension and LVH and 10 normotensive (NT) rats.
  • Systolic blood pressure was measured; capillary plasma-perfused distances, densities, and red cell content (Q) were analyzed.

Related Experiment Videos

  • Capillary red cell recruitment was assessed during hypoxia (5% O2).

    • Main Results:

    • LVH rats exhibited significantly increased plasma-perfused capillary distances (20 vs. 17.7 microns) and a 20% reduction in capillary volume, surface, and length densities compared to NT rats.
    • Capillary red cell content (Q) was higher in LVH rats (0.83 vs. 0.77).
    • During hypoxia, capillary red cell recruitment in LVH rats was diminished by 33% compared to NT rats.

    Conclusions:

    • Reduced capillary density and impaired capillary red blood cell recruitment in LVH contribute to diminished coronary vascular reserve.
    • These microcirculatory dysfunctions may explain chest pain in patients with LVH and normal coronary arteries.