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Updated: Jun 2, 2026

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
Published on: October 19, 2021
Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis
Alberto Verrotti1, Giulia Loiacono, Enzo Ballone
1Department of Pediatrics, Unit of Medical Statistics, University G. D'Annunzio of Chieti, Chieti, Italy.
Abstract:
Rufinamide is a new orally active antiepileptic drug that has been found to be effective in the treatment of partial seizures and drop attacks associated with Lennox-Gastaut syndrome. We performed a quantitative analysis of the efficacy of this new antiepileptic drug from all double-blind, add-on, randomized, placebo-controlled clinical trials published to date. Data from 918 patients were studied. The number of patients per study varied from 25 to 262. Rufinamide was efficacious in doses up to 45 mg/kg daily when provided as adjunctive therapy in patients with Lennox-Gastaut syndrome and other drug-resistant epilepsies. Further studies are needed to confirm and expand these findings.
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