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Related Experiment Video

Updated: Jun 2, 2026

SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

SUMO and its role in human diseases.

Kevin D Sarge¹, Ok-Kyong Park-Sarge

¹Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.

International Review of Cell and Molecular Biology

|April 13, 2011

Summary

Sumoylation, a protein modification, impacts proteins linked to diseases like Alzheimer's and Parkinson's. New research shows sumoylation of amyloid precursor protein (APP) and lamin A is crucial for health.

Area of Science:

Biochemistry
Molecular Biology
Cellular Regulation

Background:

Protein modification through covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, known as sumoylation, is a key regulatory mechanism.
Sumoylation influences the function of numerous proteins, many of which are implicated in significant human diseases such as cancer, Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis.

Purpose of the Study:

To identify and investigate the role of sumoylation in human disease-associated proteins.
To explore the functional implications of sumoylation on amyloid precursor protein (APP) and lamin A.

Main Methods:

Literature review of recent studies.
Analysis of protein sumoylation.

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Investigation of disease-associated protein modifications.

Main Results:

Two additional human disease-associated proteins, amyloid precursor protein (APP) and lamin A, have been identified as sumoylated.
APP sumoylation was found to modulate Aβ peptide levels, indicating a potential role in Alzheimer's disease pathogenesis.
Decreased lamin A sumoylation, resulting from mutations near its SUMO site, is implicated in familial dilated cardiomyopathy.

Conclusions:

Sumoylation is a critical regulatory process with implications for a range of human diseases.
Dysregulation of APP and lamin A sumoylation contributes to the development of Alzheimer's disease and familial dilated cardiomyopathy, respectively.