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Vaccination of children and adolescents with rheumatic diseases

Laura Dell' Era1, Susanna Esposito, Fabrizia Corona

  • 1Department of Maternal and Pediatric Sciences, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy.

Rheumatology (Oxford, England)
|April 13, 2011
PubMed

Insights

Children with rheumatic diseases (RDs) benefit from standard vaccination schedules. Pneumococcal and influenza vaccines are strongly recommended to prevent severe infections in these vulnerable patients.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Vaccinology

Background:

  • Children with rheumatic diseases (RDs) have compromised immunity and often use immunosuppressive drugs.
  • Vaccination in RDs is debated due to concerns about insufficient immune response and potential autoimmune triggers.

Purpose of the Study:

  • To review available data on vaccine risks, immunogenicity, efficacy, and tolerability in children with RDs.
  • To provide evidence-based recommendations for vaccination in this population.

Main Methods:

  • Systematic review of existing literature on vaccines in pediatric rheumatic diseases.
  • Analysis of data on immune response, protection, and adverse events following vaccination.

Main Results:

  • Vaccination is generally safe and recommended for children with RDs, following standard schedules.
  • Pneumococcal and influenza vaccinations are particularly crucial due to high infection risks in RD patients.
  • Current data indicate sufficient immunogenicity and tolerability for recommended vaccines.

Conclusions:

  • Children with RDs should adhere to recommended vaccination schedules.
  • Enhanced emphasis on pneumococcal and influenza vaccines is warranted for infection prevention.
  • Further research is needed to address specific knowledge gaps in RD vaccination.

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