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Impact at age 11 years of major neonatal morbidities in children born extremely preterm

Aijaz Farooqi1, Bruno Hägglöf, Gunnar Sedin

  • 1Institute of Clinical Sciences, Department of Pediatrics, University Hospital, SE-901 85 Umeå, Sweden. aijaz.farooqi@pediatri.umu.se

Pediatrics
|April 13, 2011
PubMed

Insights

Neonatal brain injury and severe retinopathy of prematurity (ROP) predict poor 11-year outcomes in extremely preterm infants. Bronchopulmonary dysplasia (BPD) did not independently correlate with long-term functional abilities.

Area of Science:

  • Neonatalogy
  • Pediatric Neurology
  • Ophthalmology

Background:

  • Long-term outcomes for extremely preterm infants remain uncertain.
  • Predictive value of neonatal morbidities on functional abilities needs further clarification.

Purpose of the Study:

  • To assess the impact of bronchopulmonary dysplasia (BPD), brain injury, and severe retinopathy of prematurity (ROP) on 11-year outcomes.
  • To evaluate predictors of death or major disability in infants born at <26 weeks' gestation.

Main Methods:

  • Study included 247 infants born before 26 weeks' gestation (1990-1992).
  • 98 infants survived to 36 weeks' postmenstrual age.
  • Outcomes included death after 36 weeks' postmenstrual age, major disability at 11 years, and parental-reported chronic condition consequences.

Main Results:

  • Brain injury and severe ROP independently predicted poor 11-year outcomes.
  • Infants with no neonatal morbidities had a 10% poor outcome rate.
  • Rates increased to 19% (any 1), 58% (any 2), and 80% (all 3 morbidities).
  • Brain injury and severe ROP were linked to higher rates of chronic condition consequences.

Conclusions:

  • Severe ROP and brain injury are independent predictors of death or major disability at 11 years in extremely preterm survivors.
  • Prevention of these neonatal complications is crucial for improving long-term functional abilities.
Abstract

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