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Complete blood cell count and retinal vessel diameters.
Barbara E K Klein1, Ronald Klein, Chelsea E Myers
1Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, 610 N Walnut Street, Madison, WI 53726-2336, USA. kleinb@epi.ophth.wisc.edu
Archives of Ophthalmology (Chicago, Ill. : 1960)
|April 13, 2011
Summary
Complete blood cell count components are linked to retinal vessel diameters. This includes red blood cells, hemoglobin, hematocrit, and white blood cells, impacting both arteriole and venule measurements.
Area of Science:
- Ophthalmology
- Hematology
- Vascular Biology
Background:
- Retinal vessel diameter is a key indicator of cardiovascular health.
- Complete blood cell count (CBC) parameters reflect various physiological states.
Purpose of the Study:
- To investigate the cross-sectional associations between CBC components and retinal vessel diameters.
- To determine if blood cell counts correlate with the size of retinal arterioles and venules.
Main Methods:
- Utilized data from the Beaver Dam Eye Study cohort (n=4730).
- Measured retinal arteriole and venule diameters using computer-assisted software.
- Performed complete blood cell counts and analyzed associations with retinal vessel measurements.
Main Results:
- Red blood cell count, hemoglobin, hematocrit, and white blood cell count showed significant associations with both central retinal venule equivalent and central retinal arteriole equivalent.
- Platelet count was initially associated only with central retinal venule equivalent but became significant for both vessel types in adjusted models.
Conclusions:
- Components of the complete blood cell count are significant correlates of retinal vessel diameters.
- CBC parameters should be considered in research analyzing retinal blood vessel diameters as outcomes.
