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Updated: Jun 2, 2026
07:33
Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Active and passive immunotherapy for lymphoma: proving principles and improving results
Joshua Brody1, Holbrook Kohrt, Aurelien Marabelle
1Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA. josho@stanford.edu
Summary
Immunotherapy offers new hope for lymphoma patients, utilizing the immune system to target cancer cells. Research explores monoclonal antibodies, T-cell therapies, and vaccines to improve treatment outcomes and reduce toxicity.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Conventional chemotherapy has improved lymphoma treatment but many subtypes remain incurable.
- There is a need for novel therapies with reduced toxicity and enhanced tumor cell targeting.
- The immune system, via B-cell and T-cell receptors, offers a basis for targeted lymphoma therapies.
Purpose of the Study:
- To review current immunotherapy strategies for lymphoma treatment.
- To discuss the efficacy and ongoing improvements of various immunotherapy approaches.
- To highlight the potential of novel immunotherapies in managing incurable lymphoma subtypes.
Main Methods:
- Review of passive immunotherapies including monoclonal antibodies (mAbs) and T-cell therapies.
- Exploration of active immunotherapies such as vaccines and immune checkpoint blockades.
- Discussion of emerging strategies like immunotransplantation (reinfusion of primed T cells).
Main Results:
- First-generation mAb therapies have significantly improved lymphoma care standards.
- T-cell therapies targeting viral or antibody-recognized antigens show clinical activity.
- Vaccines and immune checkpoint inhibitors are demonstrating therapeutic activity in ongoing trials.
Conclusions:
- Immunotherapy, encompassing passive and active strategies, holds significant promise for lymphoma treatment.
- Ongoing research focuses on refining existing therapies and developing novel approaches like immunotransplantation.
- Further advancements in immunotherapy are crucial for improving outcomes in patients with currently incurable lymphomas.
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