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Meningiomas: correlation of Ki67 with histological grade
Sashidhar Babu1, Shantveer G Uppin, Megha S Uppin
1Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India.
Background:
Meningiomas are slow-growing tumors. Grading of meningiomas based on histological features has certain limitations in predicting the exact biological behavior, necessitating ancillary techniques.
Objective:
To study the Ki67 labeling index (Ki67 LI) in various histological subtypes and grades of meningioma and correlate it with various parameters for recurrence.
Material And Methods:
All intracranial and intraspinal meningiomas diagnosed between 2005 and 2008 were graded according to WHO 2007 criteria. Immunohistochemistry was performed using Ki67 (Dako, USA 1:50) in 300 cases. Statistical analysis was performed. Results : There was female predominance. The age ranged from 2-75 years including 11 children below the age of 18 years. There were 211 Grade I, 78 Grade II and 11 Grade III meningiomas. The mean Ki67 LI increased from Grade I to II and from Grade II to III and these were statistically significant. The Ki67 LI was high for the subtypes of clear cell, chordoid, papillary and rhabdoid but there was no statistical significance between the subtypes. The difference in Ki67 LI between recurrent versus non-recurrent and brain-invasive versus non-invasive meningiomas was statistically significant.
Conclusion:
High Ki67 LI indicates higher grade of meningioma. The difference in KI67 LI between recurrent and non-recurrent meningiomas was statistically significant.
Insights
High Ki67 labeling index (LI) in meningiomas correlates with higher tumor grade and recurrence risk. This marker aids in predicting meningioma behavior beyond traditional histological grading.
Area of Science:
- Neuro-oncology
- Tumor biology
- Histopathology
Background:
- Meningiomas are typically slow-growing tumors.
- Histological grading has limitations in predicting biological behavior.
- Ancillary techniques are necessary for accurate prognosis.
Purpose of the Study:
- To evaluate the Ki67 labeling index (LI) in diverse meningioma subtypes and grades.
- To correlate Ki67 LI with prognostic parameters, particularly recurrence.
- To establish Ki67 LI as a predictive marker for meningioma behavior.
Main Methods:
- Analysis of 300 intracranial and intraspinal meningiomas diagnosed between 2005-2008.
- WHO 2007 criteria used for tumor grading.
- Immunohistochemistry performed using Ki67 antibody (Dako, USA 1:50).
- Statistical analysis to correlate Ki67 LI with grade, subtype, and recurrence.
Main Results:
- Female predominance observed in the study cohort.
- Mean Ki67 LI significantly increased from WHO Grade I to III.
- Elevated Ki67 LI noted in specific subtypes (clear cell, chordoid, papillary, rhabdoid) without statistical significance.
- Significant differences in Ki67 LI between recurrent vs. non-recurrent and brain-invasive vs. non-invasive meningiomas.
Conclusions:
- Ki67 labeling index is a significant indicator of meningioma grade.
- Higher Ki67 LI is associated with increased risk of recurrence.
- Ki67 LI serves as a valuable prognostic marker for meningiomas.
