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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
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A Hot Cross Bun sign from diffusion tensor imaging and tractography perspective.

Kok Beng Loh1, Kartini Rahmat, Shen-Yang Lim

  • 1Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. kokbeng.loh@gmail.com

Neurology India
|April 13, 2011
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Summary

The "Hot Cross Bun" sign on MRI may not spare corticospinal tracts (CST), contrary to prior beliefs. Diffusion tensor imaging and tractography support neuropathologic findings, showing CST involvement in this imaging sign.

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Radiology

Background:

  • The
  • Hot Cross Bun
  • sign on T2-weighted MRI suggests selective pontine fiber and neuron loss with corticospinal tract (CST) preservation.

Observation:

  • Neuropathologic studies have contradicted the preservation of CST in the
  • Hot Cross Bun
  • sign.

Findings:

  • This study provides pictorial and quantitative evidence using diffusion tensor imaging and tractography.
  • The imaging findings are consistent with neuropathologic data, indicating no sparing of the CST.

Implications:

  • Revises the understanding of the
  • Hot Cross Bun
  • sign's underlying pathology.
  • Highlights the utility of diffusion tensor imaging and tractography in demonstrating neuropathologic findings.