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Related Concept Videos

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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Related Experiment Video

Updated: Jun 2, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Hansen's disease mimicking a systemic vasculitis.

L Sampaio1, L Silva, G Terroso

  • 1Serviços de Reumatologia do Hospital de São João e da Faculdade de Medicina do Porto, Portugal. luziasampaio@hotmail.com

Acta Reumatologica Portuguesa
|April 13, 2011
PubMed
Summary

Hansen's disease, or leprosy, can cause unusual rheumatologic symptoms like polyarthritis and leg ulcers. This case highlights leprosy as a rare cause of these conditions in non-endemic areas.

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Published on: September 14, 2010

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Dermatology

Background:

  • Hansen's disease (leprosy) is caused by Mycobacterium leprae.
  • Classic symptoms include skin and nerve issues.
  • Rheumatologic manifestations occur in 1-5% of patients.

Observation:

  • An 86-year-old woman presented with polyarthritis, subcutaneous nodules, and leg ulcers.
  • Initial differential diagnoses included primary vasculitis and diffuse connective tissue diseases.

Findings:

  • The patient's presentation was ultimately diagnosed as leprosy.
  • This diagnosis was made despite the patient residing in a non-endemic country.

Implications:

  • This case underscores the importance of considering leprosy in the differential diagnosis of rheumatologic conditions.
  • It highlights the varied clinical presentations of Hansen's disease, even in non-endemic regions.
  • Early diagnosis of leprosy is crucial for effective treatment and management.