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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Association between Blood Lipids and Types of Stroke

Sergio González1, Otman Fernández, Rebeca Fernández

  • 1Institute of Neurology and Neurosurgery, Havana, Cuba. sergiogg@infomed.sld.cu.

MEDICC Review
|April 13, 2011
PubMed

Insights

Serum lipid levels are linked to stroke type. Elevated total cholesterol, LDL, and triglycerides correlate with atheromatous cerebral infarction (CI), while low cholesterol and high triglycerides are associated with cerebral hemorrhage (CH).

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Epidemiology

Background:

  • Previous studies on blood lipids and cerebrovascular disease lacked specificity regarding stroke types.
  • Differentiating between stroke subtypes is crucial for understanding the relationship between lipid profiles and neurological outcomes.

Purpose of the Study:

  • To investigate the association between serum lipid levels and the incidence of different stroke types, specifically cerebral infarction (CI) and cerebral hemorrhage (CH).
  • To explore the relationship between lipid profiles and etiological subtypes of CI, including atheromatous CI.

Main Methods:

  • Two case-control studies were conducted.
  • Study 1 compared lipid levels in patients with CI, CH, and healthy controls.
  • Study 2 compared lipid levels in patients with atheromatous CI, non-atheromatous CI, and healthy controls, assessing the influence of age, sex, and risk factors.

Main Results:

  • Cerebral infarction (CI) patients exhibited higher total cholesterol, LDL cholesterol, and triglyceride levels compared to controls.
  • Cerebral hemorrhage (CH) patients showed lower total cholesterol but higher triglyceride levels than controls.
  • A significant association between lipid levels and CI was observed specifically in atheromatous stroke cases, particularly in women, independent of other risk factors.

Conclusions:

  • The etiological subtype of stroke is critical when examining the link between blood lipids and stroke occurrence.
  • Elevated total cholesterol, LDL, and triglycerides are associated with atheromatous CI.
  • Low total cholesterol and high triglycerides are linked to the occurrence of CH.
Abstract

Keywords:
cholesterolHDLLDLtriglyceridescerebral hemorrhagecerebral infarctionatherosclerosisvascular diseasescerebrovascular disordersstrokecerebrovascular accidentCVAischemiahyperlipidemias

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