Therapeutic options for intermediate-advanced hepatocellular carcinoma

Area of Science:

• Hepatology
• Oncology
• Surgical Oncology

Background:

• Hepatocellular carcinoma (HCC) is a globally prevalent malignancy, with a significant burden in China.
• Late-stage diagnosis of HCC often limits treatment choices.
• Surgical resection, while curative, is not suitable for most intermediate-advanced HCC cases.

Purpose of the Study:

• To review and discuss the therapeutic modalities for intermediate-advanced hepatocellular carcinoma.
• To provide insights into the selection of appropriate treatments for HCC patients.

Main Methods:

• This review synthesizes current knowledge on treatment options for intermediate-advanced HCC.
• It examines surgical procedures, interventional treatments, and molecularly targeted therapies.

Main Results:

• Current treatment strategies for intermediate-advanced HCC encompass surgical resection, ablation, transplantation, transcatheter arterial chemoembolization, and targeted therapies.
• The optimal choice of treatment modality remains a subject of ongoing debate.

Conclusions:

• Choosing the most effective treatment for intermediate-advanced HCC presents a significant challenge for clinicians.
• A comprehensive understanding of available therapeutic options is crucial for patient management.