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Hsa-miR-196a2 Rs11614913 polymorphism contributes to cancer susceptibility: evidence from 15 case-control studies

Haiyan Chu1, Meilin Wang, Danni Shi

  • 1Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Department of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.

Plos One
|April 13, 2011
PubMed
Abstract

Insights

The hsa-miR-196a2 rs11614913 polymorphism is linked to increased cancer risk. This genetic variation may influence susceptibility, particularly for breast and lung cancers in Asian populations.

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression.
  • The hsa-miR-196a2 rs11614913 polymorphism has been investigated for its association with cancer risk, yielding inconclusive results.
  • Understanding miRNA gene variations is crucial for cancer susceptibility research.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between the hsa-miR-196a2 rs11614913 polymorphism and cancer risk.
  • To evaluate the potential role of this polymorphism in modulating the risk of specific cancer types.
  • To investigate population-specific risks associated with the hsa-miR-196a2 rs11614913 polymorphism.

Main Methods:

  • Meta-analysis of 15 studies involving 9,341 cancer cases and 10,569 controls.
  • Statistical assessment using odds ratios (ORs) with 95% confidence intervals (CIs).
  • Stratified analyses were performed to examine associations with specific cancer types and ethnic groups.

Main Results:

  • The TC/CC genotypes of hsa-miR-196a2 rs11614913 were associated with a significantly higher overall cancer risk (OR=1.18).
  • The CC genotype showed a potential association with increased breast cancer risk (OR=1.11) and lung cancer risk (OR=1.25).
  • A significantly increased cancer risk was observed among Asian populations in a dominant model (OR=1.24).

Conclusions:

  • The hsa-miR-196a2 rs11614913 polymorphism is a potential contributing factor to cancer susceptibility.
  • This genetic variation may play a role in the development of specific cancers like breast and lung cancer.
  • Further research is warranted to elucidate the precise mechanisms linking this polymorphism to cancer.

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