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P-wave dispersion in systemic AA amyloidosis of familial Mediterranean fever

Udi Nussinovitch1, Avi Livneh, Moshe Nussinovitch

  • 1The Heller Institute of Medical Research and Department of Medicine F, Sheba Medical Center, Tel Hashomer, Israel. enussi@yahoo.com

Clinical Rheumatology
|April 13, 2011
PubMed

Insights

Familial Mediterranean Fever (FMF) patients with amyloidosis show normal atrial conduction. This suggests they do not have an increased risk for supraventricular arrhythmias compared to healthy individuals.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder.
  • FMF is characterized by recurrent episodes of fever and polyserositis.
  • Previous research is conflicting regarding FMF's association with atrial electrical activity markers.

Purpose of the Study:

  • To investigate atrial dispersion in FMF patients with amyloidosis.
  • To compare electrocardiographic parameters between FMF patients and healthy controls.

Main Methods:

  • 12-lead electrocardiography was performed on 16 FMF patients with amyloidosis and 16 matched controls.
  • P-wave duration and P-wave dispersion were calculated from random and averaged electrocardiogram beats.
  • Statistical analysis compared these parameters between the study groups.

Main Results:

  • No significant differences were observed in P-wave duration or P-wave dispersion between FMF patients and controls.
  • Calculations from both random and averaged beats yielded similar results.
  • Atrial conduction parameters were comparable in both groups.

Conclusions:

  • FMF patients with amyloidosis exhibit normal atrial conduction.
  • These findings suggest no increased electrocardiographic risk for supraventricular arrhythmias in this patient group.
  • Further research with larger cohorts may be warranted to confirm these results.

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