Related Experiment Video

Updated: Jun 2, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

[The early postnatal weight gain as a predictor of retinopathy of prematurity]

S Flückiger1, H U Bucher, A Hellström

  • 1Klinik für Neonatologie, UniversitätsSpital Zürich, Schweiz. sarah_flk@hotmail.com

Klinische Monatsblatter Fur Augenheilkunde
|April 13, 2011
PubMed

Insights

The WINROP algorithm effectively predicts retinopathy of prematurity (ROP) in Swiss preterm infants, potentially reducing unnecessary eye exams. This method uses early postnatal weight gain to identify high-risk infants.

Area of Science:

  • Neonatology
  • Ophthalmology
  • Pediatrics

Context:

  • Current retinopathy of prematurity (ROP) screening is stressful for premature infants.
  • Less than 10% of screened infants require ROP treatment, indicating an inefficient screening process.
  • Existing guidelines for ROP screening do not incorporate crucial postnatal factors.

Purpose:

  • To evaluate the predictive accuracy of the WINROP algorithm in a Swiss preterm infant population.
  • To assess the WINROP algorithm's ability to identify infants at high risk for severe ROP.
  • To determine if the WINROP algorithm can optimize ROP screening protocols.

Summary:

  • A retrospective study analyzed 376 preterm infants (GA < 32 weeks or BW ≤ 1500 g) using a modified WINROP algorithm based on weekly postnatal weight gain.
  • The WINROP algorithm issued a "high-risk" alarm for 58 infants.
  • Of those flagged, eight developed severe ROP, and four required laser therapy.

Impact:

  • The WINROP algorithm demonstrated high predictive value in Swiss preterm infants, confirming its clinical utility.
  • Implementing the WINROP algorithm could significantly simplify current ROP screening procedures.
  • This approach has the potential to substantially decrease the number of required ophthalmoscopies, reducing healthcare costs and infant stress.
Abstract

More Related Videos

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...