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Updated: Jun 2, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Oleanane-type triterpene saponins and cassaine-type diterpenoids from Erythrophleum fordii
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Abstract:
Phytochemical investigation of the EtOH extract of the leaves of Erythrophleum fordii led to the isolation of two oleanane-type triterpene saponins (1-2) and five cassaine-type diterpenoids (4-8) along with one known methyl 3 β-hydroxy-erythrosuamate (3). Their structures were established by extensive NMR, as well as ESI-MS analyses and acid hydrolysis. Biological evaluation of compounds 3- 8 against five human cancer cell lines revealed that compounds 5-7 exhibited potent cytotoxic activity with IC₅₀ values ranging from 1.51 to 8.68 µM.
