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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

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Related Experiment Video

Updated: Jun 2, 2026

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

WNT10A and isolated hypodontia.

Piranit Kantaputra¹, Warissara Sripathomsawat

¹Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Craniofacial Genetics Laboratory, Chiang Mai University, Thailand. dentaland17@gmail.com

American Journal of Medical Genetics. Part A

|April 13, 2011

Summary

This summary is machine-generated.

Mutations in the WNT10A gene are linked to ectodermal dysplasia syndromes. This study identifies WNT10A mutations as a cause of isolated hypodontia in an American family.

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

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Last Updated: Jun 2, 2026

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

Genetics
Developmental Biology
Oral Health

Background:

WNT10A mutations are associated with several ectodermal dysplasia syndromes, including Schöpf-Schulz-Passarge syndrome and odonto-onycho-dermal dysplasia.
Previous research has linked genes like MSX1, PAX9, AXIN2, and EDA to hypodontia.

Observation:

This study investigates WNT10A mutations in an American family.
Four family members presented with isolated hypodontia or microdontia.

Findings:

WNT10A mutations were identified in affected family members.
This demonstrates that WNT10A mutations can cause isolated hypodontia, expanding the known genetic causes.

Implications:

WNT10A is implicated as a causative gene for isolated hypodontia.
This finding broadens the understanding of genetic factors contributing to tooth agenesis.
Further research into WNT10A's role in craniofacial development is warranted.