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Levodopa-responsive parkinsonism in a patient with Down's syndrome
C Singer1, J Sanchez-Ramos, W J Weiner
1Department of Neurology, University of Miami School of Medicine, Fla.
European Neurology
|January 1, 1990
Abstract:
We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.