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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

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Scenario of acute respiratory distress syndrome in a tertiary care center

S Lakhey1, R Shrestha, S Thapa

  • 1Departmant of Medicine, B & B Hospital, Gwarko Kathmandu, Nepal. sanjaylakhey65@yahoo.com

JNMA; Journal of the Nepal Medical Association
|April 14, 2011
PubMed

Insights

Acute respiratory distress syndrome (ARDS) has high mortality, with sepsis as a common cause. Lower oxygen levels and higher SOFA scores predict death in ARDS patients.

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Intensive Care Unit (ICU) Studies

Background:

  • Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxic respiratory failure and non-cardiogenic pulmonary edema.
  • ARDS presents with diverse etiologies and carries a high mortality rate.
  • Understanding ARDS predictors is crucial for improving patient outcomes in the ICU.

Purpose of the Study:

  • To investigate the primary etiologies of ARDS.
  • To analyze physiological variables and their association with mortality.
  • To identify predictors of mortality in ICU patients with ARDS.

Main Methods:

  • A prospective, cross-sectional study included patients over 14 years old meeting American-European Consensus Conference criteria for ARDS.
  • Data collected on patient demographics, etiologies, physiological parameters, and outcomes.
  • Statistical analysis to identify factors associated with mortality.

Main Results:

  • Sepsis (30.7%), polytrauma (25%), and fat embolism syndrome (25%) were the leading ARDS etiologies.
  • Hospital mortality was 38.9%, with multi-organ failure (MOF) being the most common cause of death.
  • Non-survivors exhibited lower pH, lower PaO2/FiO2 on day 3, and higher SOFA scores; a SOFA score ≥13 predicted death.

Conclusions:

  • Sepsis is a primary etiology, and MOF is the leading cause of death in ARDS.
  • ARDS is associated with high mortality, comparable to existing literature.
  • Impaired oxygenation, lower pH, and elevated SOFA scores are significant predictors of mortality in ARDS patients.
Abstract

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