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Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

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Sigmoidoscopy
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Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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Related Experiment Video

Updated: Jun 2, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Perioperative melatonin use.

J Jarratt1

  • 1Department of Anaesthesia, Christchurch Hospital, Christchurch, New Zealand.

Anaesthesia and Intensive Care
|April 14, 2011
PubMed
Summary

Melatonin, a key sleep hormone with antioxidant roles, is increasingly used perioperatively. Patients on melatonin supplements may benefit from continuing them during surgery due to potential advantages.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Sleep Medicine

Background:

  • Melatonin is a hormone primarily produced by the pineal gland, regulating the sleep-wake cycle.
  • It possesses significant antioxidant properties and is available exogenously with a short half-life.
  • Newer melatonin analogues targeting MT1 and MT2 receptors have been developed.

Purpose of the Study:

  • To review the role and applications of melatonin and its analogues in perioperative care.
  • To discuss the potential benefits of continuing melatonin supplementation perioperatively.
  • To highlight the increasing relevance of melatonin in surgical settings.

Main Methods:

  • Literature review of studies on melatonin's physiological roles and clinical applications.
  • Analysis of research concerning melatonin's use as a premedicant, sedative, and analgesic.

Related Experiment Videos

Last Updated: Jun 2, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

  • Examination of studies investigating melatonin's antioxidant effects in conditions like sepsis and reperfusion injury.

    • Main Results:

    • Exogenous melatonin is utilized for jet lag and sleep disturbances, with analogues targeting specific receptors.
    • Perioperative applications include pre-medication, sedation, analgesia, and reducing pediatric emergence delirium.
    • Melatonin's antioxidant properties are under investigation for sepsis and reperfusion injuries.

    Conclusions:

    • Patients on melatonin supplements may benefit from continuing them during the perioperative period.
    • Melatonin and its analogues are expected to be more frequently encountered in perioperative settings.
    • The multifaceted roles of melatonin warrant consideration in surgical patient management.