Related Experiment Video
Updated: Jun 2, 2026
04:18
Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Multiparity, perinatal morbidity and mortality
A Andrejevic1, S Cvetkovic, Z Vitosevic
1Gynecological Clinic, Faculty of Medicine, Pristina-Kosovska Mitrovica. doktoraleksa@yahoo.com
Clinical and Experimental Obstetrics & Gynecology
|April 14, 2011
Summary
Grand multiparity, defined as six or more deliveries, significantly increases risks for newborns and mothers. This study highlights higher rates of low birth weight, lower Apgar scores, and increased perinatal mortality in grand multiparous women.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Medicine
- Public Health
Background:
- Multiparity presents significant medical and social challenges globally.
- Clinicians aim to identify and prevent perinatal morbidity and mortality causes.
Purpose of the Study:
- To investigate the impact of grand multiparity (≥6 deliveries) on perinatal morbidity and mortality.
- To analyze factors influencing newborn vitality in relation to parity.
Main Methods:
- A retrospective study of 12,532 deliveries at a Gynecological Clinic (1992-1993).
- Defined grand multiparity as six or more childbirths.
- Focused analysis on factors affecting newborn vitality.
Main Results:
- Grand multiparity is associated with lower birth weight and hypotrophic infants.
- Apgar scores decline with increasing parity; respiratory and CNS issues are more prevalent.
- Congenital anomalies, mother, and infant mortality rates are notably higher.
Conclusions:
- Grand multiparity poses elevated risks for both newborns and mothers.
- Increased perinatal morbidity and mortality are significant concerns.
- Pregnancy, delivery, and puerperium present heightened risks, potentially endangering maternal life.
Related Concept Videos
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
01:24Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
01:19Mitral Valve Prolapse III: Nursing Management
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...