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Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

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Related Experiment Video

Updated: Jun 2, 2026

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Inflammation in depression: is adiposity a cause?

Richard C Shelton1, Andrew H Miller

  • 1Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA. richard.shelton@vanderbilt.edu

Dialogues in Clinical Neuroscience
|April 14, 2011
PubMed
Summary
This summary is machine-generated.

Inflammation, particularly from adiposity, is increasingly linked to depression. Targeting this inflammation may offer new treatments for depression and related conditions like cardiovascular disease.

More Related Videos

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

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Last Updated: Jun 2, 2026

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Growing evidence links inflammation to depression development.
  • Depression is associated with elevated inflammatory markers.
  • Cytokine administration can induce depressive symptoms.

Purpose of the Study:

  • To explore the role of inflammation, especially from adiposity, in depression.
  • To investigate the bidirectional relationship between adiposity and depression.
  • To identify potential therapeutic targets for depression and comorbid disorders.

Main Methods:

  • Review of evidence linking inflammation and depression.
  • Examination of mechanisms of cytokine action in the brain.
  • Analysis of the relationship between adipose tissue and inflammatory factors.

Main Results:

  • Adiposity is a significant source of inflammation in depression.
  • A vicious cycle exists between adiposity and depression, mediated by inflammation.
  • Inflammatory pathways are implicated in the pathophysiology of depression.

Conclusions:

  • Inflammation, driven by adiposity, is a key factor in depression.
  • Targeting the inflammation-adiposity-depression axis may treat depression.
  • This approach could also benefit comorbid conditions like cardiovascular disease, diabetes, and cancer.