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Updated: Jun 2, 2026

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
Published on: May 26, 2023
Methodological approaches influencing cellular uptake and cyto-(geno) toxic effects of nanoparticles
Laetitia Gonzalez1, Sara Corradi, Leen C J Thomassen
1Laboratory for Cellular Genetics, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Abstract:
Methods are needed to assess cytotoxicity and genotoxicity of nanoparticles (NPs). The influence of serum and the use of cytochalasin-B were assessed on the cellular uptake of amorphous silica NPs (SNPs) and their biological effects. Our observations indicate that some methodological approaches may modulate the outcome of the assay. Therefore the experimental design and choice of the assays are of great importance in nanotoxicology.
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