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Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Published on: June 18, 2013
Doxorubicin encapsulated nanocarriers for targeted delivery to estrogen responsive breast cancer
Shivani Rai1, Rishi Paliwal, Suresh P Vyas
1Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar 470003, M.P, India.
Abstract:
The encapsulation of anticancer agent in carrier system protects healthy tissues from its cytotoxic effects. In the present study estrogen receptor targeted liposomes encapsulating doxorubicin was designed to enhance the efficiency of delivery of doxorubicin to its destination site. The liposomal formulations showed change in the biodistribution profile. Targeted formulation accumulates more in breast and uterine tissues. ER-targeted formulation of antineoplastic agents could be potentially useful for treatment of ER positive tumors such as breast and uterus.
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