EGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancer
Sahil Aggarwal1, Sachin Yadav, Swati Gupta
1Nanomedicine Research Centre, Department of Pharmaceutics, I.S.F College of Pharmacy, Moga 142001, India.
Journal of Biomedical Nanotechnology
|April 14, 2011
Abstract:
The present study aimed to prepare and characterize anti EGFR monoclonal antibody (mab) conjugated Gemcitabine loaded PLGA nanoparticles for their selective delivery to pancreatic cells and evaluation of the systems in vitro. It was observed that direct covalent coupling of antibodies to glutaraldehyde activated nanoparticles is an appropriate method to achieve cell-type specific drug carrier systems based on polymeric nanoparticles that have potential to be applied for targeted chemotherapy in EGFR positive cancer.
