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Updated: Jun 2, 2026

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
Published on: March 3, 2020
Evaluation of safety of lipomer doxycycline hydrochloride (lipomer DH)
Rohit Dhumal1, Mahesh Soni, Padma Devarajan
1National Center for Preclinical Reproductive and Genetic Toxicology, National Institute for Research in Reproductive Health, Parel, Mumbai 400012, India.
Abstract:
The nanoparticulate formulation of lipomer doxycycline hydrochloride (lipomer DH) has been synthesized for the treatment of Brucellosis to increase efficacy of the drug. The present study was undertaken to determine the intravenous safety of blank lipomer and Lipomer DH in terms of maximum tolerated dose in rats. It was observed that blank lipomer and lipomer DH were safe when administered intravenously at doses 2000 mg/kg Bw and 18 mg/kg bw respectively.
