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Updated: Jun 2, 2026
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
Published on: June 26, 2020
Interaction of C60 fullerene with the proteins involved in DNA mismatch repair pathway
Shishir Kumar Gupta1, Lokesh Baweja, Deepak Gurbani
1Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, M. G. Marg, Lucknow 226001, India.
Abstract:
Fullerenes are fascinating symmetric carbon nanostructures with a potential to bind DNA and proteins. Computational studies were performed to investigate the interaction of fullerenes with the proteins involved in DNA mismatch repair (MMR) pathway. Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed. These findings suggested that fullerene interferes in the human MMR process hence the subsequent disturbance may confer a large increase in spontaneous mutability and a strong predisposition to tumor development.
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