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Inhibitory effect of açaí (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation
Tomoko Horiguchi1, Nahoko Ishiguro, Kazuyasu Chihara
1Laboratory of Biochemistry, Graduate School of Life Science, Kobe Women's University, Kobe, Japan.
Abstract:
The palm fruit açaí is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, açaí suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Açaí could selectively inhibit FcεRI signaling pathways. Furthermore, the FcεRI-mediated complementary signaling pathway was also suppressed by açaí. These results demonstrate that açaí is a potent inhibitor of IgE-mediated mast cell activation.
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