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Published on: May 7, 2012
Cytomegalovirus prostatitis in a heart transplant recipient
N G Rouphael1, S R Laskar, A Smith
1Division of Infectious Diseases Center for Heart Failure and Heart Transplantation, Emory University School of Medicine, Atlanta, GA, USA. nroupha@emory.edu
Summary
Cytomegalovirus (CMV) prostatitis is rare in heart transplant recipients. This case highlights CMV
Area of Science:
- Transplantation immunology
- Viral infections
- Urology
Background:
- Cytomegalovirus (CMV) is a common post-transplant complication.
- Prostate involvement by CMV is exceptionally rare, even in immunocompromised patients.
Observation:
- A 59-year-old heart transplant recipient presented with an elevated prostate-specific antigen (PSA).
- Prostate biopsy revealed adenocarcinoma, chronic prostatitis, and viral cytopathic effects indicative of CMV infection.
- CMV polymerase chain reaction (PCR) in blood was negative despite prior CMV viremia.
Findings:
- The study details the first reported case of CMV prostatitis in a heart transplant recipient.
- The patient received treatment for CMV viremia with ganciclovir, valganciclovir, and CMV immunoglobulins.
- Successful management involved brachytherapy for prostate cancer and continued anti-CMV therapy.
Implications:
- This case underscores the importance of considering CMV prostatitis in heart transplant recipients with urological symptoms.
- It highlights the complex interplay between CMV infection, prostate cancer, and immunosuppression after heart transplantation.
- Further research is needed to understand CMV's role in prostate pathology and optimize treatment strategies.
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