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Published on: September 17, 2014
Sulfacetamide loaded Eudragit® RL100 nanosuspension with potential for ocular delivery
Bivash Mandal1, Kenneth S Alexander, Alan T Riga
1Industrial Pharmacy Division, Department of Pharmacy Practice, College of Pharmacy, University of Toledo, OH 43066, USA. bm2306@gmail.com
Summary
Sulfacetamide nanosuspension using Eudragit® RL100 enhances intraocular drug delivery for bacterial infections. The formulation showed good stability and redispersibility, indicating its potential as an ocular drug delivery system.
Area of Science:
- Pharmaceutical Nanotechnology
- Ocular Drug Delivery
Background:
- Bacterial infections pose a significant threat to ocular health.
- Improving the intraocular availability of antimicrobial agents is crucial for effective treatment.
Purpose of the Study:
- To develop a polymeric nanosuspension of sulfacetamide using Eudragit® RL100.
- To enhance the intraocular availability of sulfacetamide for treating bacterial eye infections.
Main Methods:
- Nanosuspensions were prepared via solvent displacement using acetone and Pluronic® F108.
- Characterization included particle size, zeta potential, FTIR, DSC, PXRD, entrapment efficiency, and in vitro release.
- Freeze drying, redispersibility, and stability studies were conducted.
Main Results:
- Spherical nanoparticles (<500 nm) with positive zeta potential were achieved.
- High drug entrapment efficiency was optimized by adjusting pH and adding polymethyl methacrylate.
- The freeze-dried nanosuspension demonstrated good stability and redispersibility with cryoprotectants.
Conclusions:
- Eudragit® RL100 nanosuspension is a promising system for ocular sulfacetamide delivery.
- This formulation could effectively treat intraocular bacterial infections.
- Further development may lead to improved therapeutic outcomes for eye infections.
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