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Control of nuclear receptor activities in metabolism by post-translational modifications

Wahiba Berrabah1, Pierrette Aumercier, Philippe Lefebvre

  • 1Université Lille Nord de France, INSERM, U1011, Lille, France.

FEBS Letters
|April 14, 2011
PubMed

Insights

Nuclear receptors (NRs) regulate cellular responses to endocrine and dietary signals. Post-translational modifications (PTMs), especially phosphorylation, fine-tune NR activity, impacting metabolic events.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Nuclear receptors (NRs) are crucial for adapting cellular transcription to environmental signals.
  • Ligand binding activates NRs, but precise regulation involves complex mechanisms.
  • Post-translational modifications (PTMs) offer a sophisticated layer of control over NR function.

Purpose of the Study:

  • To review the role of PTMs in regulating NR activity.
  • To specifically examine the impact of phosphorylation on metabolic NR function.

Main Methods:

  • Literature review focusing on PTMs and NR regulation.
  • Analysis of studies investigating phosphorylation of metabolic NRs.

Main Results:

  • PTMs, including phosphorylation, are essential for fine-tuning NR transcriptional activity.
  • These modifications allow adaptation to tissue-specific and organismal needs.
  • Phosphorylation plays a significant role in modulating the function of NRs involved in metabolic control.

Conclusions:

  • PTMs are critical regulators of NR function, particularly for metabolic pathways.
  • Understanding NR phosphorylation provides insights into metabolic regulation and potential therapeutic targets.

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