Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

Drugs for Treatment of Diarrhea-Predominant IBS

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immunological knowledge.

Nature immunology·2026

Same author

The effects of a hydrolyzed protein diet on the plasma, fecal and urine metabolome in cats with chronic enteropathy.

Scientific reports·2023

Same author

The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy.

Scientific reports·2022

Same author

Hypercoagulability in dogs with chronic enteropathy and association with serum albumin concentration.

Journal of veterinary internal medicine·2021

Same author

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy.

PloS one·2019

Same author

Exploring early life events including diet in cats presenting for gastrointestinal signs in later life.

The Veterinary record·2019

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Published on: December 27, 2024

Antibiotic-responsive diarrhea in small animals.

Edward J Hall¹

¹School of Veterinary Sciences, University of Bristol, Langford, Bristol, England. dred.hall@bristol.ac.uk

The Veterinary Clinics of North America. Small Animal Practice

|April 14, 2011

Summary

This summary is machine-generated.

Antibiotic-responsive diarrhea (ARD) in dogs is a chronic condition that improves with antibiotics, though the exact cause remains unclear. Current research explores the gut bacteria and intestinal lining interaction to understand ARD

More Related Videos

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Ginger Moxibustion, A Non-pharmacological Treatment, for Diarrhea in Patients with Chronic Obstructive Pulmonary Disease

Published on: December 27, 2024

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Area of Science:

Veterinary Medicine
Canine Gastroenterology
Microbiome Research

Background:

Antibiotic-responsive diarrhea (ARD) is a common cause of chronic diarrhea in young, large-breed dogs.
The underlying mechanisms of ARD are poorly understood, with previous theories of small intestinal bacterial overgrowth now being questioned.
The efficacy of antibiotics suggests a role for the gut microbiota, but the precise nature of this involvement is unknown.

Purpose of the Study:

To investigate the idiopathic syndrome of antibiotic-responsive diarrhea (ARD) in dogs.
To explore the reasons behind the effectiveness of antibiotic treatment in managing chronic diarrhea.
To shift focus from bacterial overgrowth to the complex interactions between small intestinal bacteria and the intestinal mucosa.

Main Methods:

Review of existing literature on canine antibiotic-responsive diarrhea.
Analysis of clinical observations and diagnostic approaches for ARD.
Exploration of current research trends focusing on the gut microbiome and mucosal interactions in affected dogs.

Main Results:

The exact cause of antibiotic-responsive diarrhea (ARD) in dogs remains idiopathic.
The hypothesis of small intestinal bacterial overgrowth as the primary cause of ARD is increasingly doubted.
Current research is investigating the interaction between small intestinal bacteria and the gut mucosa to elucidate ARD's pathogenesis.

Conclusions:

Antibiotic-responsive diarrhea (ARD) is a syndrome characterized by its response to antibiotics, not necessarily by bacterial overgrowth.
Understanding the interaction between the canine gut microbiota and the intestinal lining is crucial for unraveling the pathophysiology of ARD.
Further research into these interactions is needed to develop targeted therapies for canine chronic diarrhea.