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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Discovery of small molecule human FPR1 receptor antagonists

John Unitt1, Malbinder Fagura, Tim Phillips

  • 1AstraZeneca R&D Charnwood, Bioscience, Bakewell Road, Loughborough LE11 5RH, UK.

Bioorganic & Medicinal Chemistry Letters
|April 14, 2011
PubMed
Summary

Two novel series of formyl peptide receptor 1 (FPR1) antagonists were identified. These compounds selectively inhibit FPR1 activity in human neutrophils, serving as valuable research tools.

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