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Updated: Jun 2, 2026

Genetic Modification and Recombination of Salivary Gland Organ Cultures
Published on: January 28, 2013
Dynamics of salivary gland morphogenesis
J Harunaga1, J C Hsu, K M Yamada
1Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg. 30, Room 426, 30 Convent Drive, MSC 4370, Bethesda, MD 20892-4370, USA.
None:
Salivary glands form during embryonic development by a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The architecture of these glands is generated by branching morphogenesis, revealed by recent research to involve unexpectedly dynamic cell motility and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Here we review these recent advances and their potential application to salivary gland tissue engineering.
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