Related Experiment Video

Updated: Jun 2, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

INPP4B: the new kid on the PI3K block

Irina U Agoulnik1, Myles C Hodgson, Wayne A Bowden

  • 1Herbert Wertheim College of Medicine, Miami, FL, USA.

Oncotarget
|April 14, 2011
PubMed

Insights

Inositol Polyphosphate 4-phosphatase type II (INPP4B) is emerging as a crucial tumor suppressor. Its dysregulation impacts phosphatidyl inositol signaling in various cancers, making it a key focus for research.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Phosphatidyl inositol signaling pathway dysregulation is implicated in numerous cancers.
  • PTEN (Phosphatase and Tensin homology protein on chromosome 10) is a well-established tumor suppressor frequently inactivated in malignancies.
  • Emerging evidence highlights Inositol Polyphosphate 4-phosphatase type II (INPP4B) as a potential tumor suppressor in prostate, breast, ovarian cancers, and leukemia.

Purpose of the Study:

  • To review the structure and function of INPP4B.
  • To explore the crosstalk between INPP4B and androgen receptor signaling.
  • To examine the regulation of INPP4B expression and its role in cancer.

Main Methods:

  • Literature review of existing research on INPP4B.
  • Analysis of structural and functional data.
  • Examination of studies on gene expression and signaling pathways.

Main Results:

  • INPP4B functions as a lipid phosphatase, counteracting pro-survival signaling pathways.
  • Its expression is altered in various cancer types, suggesting a tumor-suppressive role.
  • Crosstalk with androgen receptor signaling pathways is evident, particularly in prostate cancer.

Conclusions:

  • INPP4B is a significant tumor suppressor with a critical role in regulating cell growth and survival.
  • Understanding INPP4B's function and regulation offers potential therapeutic targets for cancer treatment.
  • Further research into INPP4B is warranted to fully elucidate its mechanisms in different malignancies.

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