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Published on: May 29, 2020
Hepatosplenic gamma/delta T-cell lymphoma masquerading as alcoholic hepatitis and methadone withdrawal
H A Lopez Morra1, S N Fine, G Dickstein
1Department of Medicine, MetroWest Medical Center, Framingham Union Hospital, Framingham, Mass., USA.
Abstract:
Hepatosplenic gamma/delta T-cell lymphoma is a rare neoplasm of mature gamma/delta T-cells with sinusoidal infiltration of spleen, liver, and bone marrow. Patients are predominantly adolescent and young adult males and usually present with marked hepatosplenomegaly. Pancytopenia is another common finding. Despite an initial response to treatment, patients have a median survival of one to two years. In this report, we document a case of alcoholic hepatitis and methadone withdrawal masquerading unsuspected, hepatosplenic gamma/delta T-cell lymphoma with unusual CD20 positivity.
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