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Phasic plasma atrial natriuretic polypeptide changes in DOCA-salt hypertensive rats
1Fourth Department of Internal Medicine, School of Medicine, University of Tokyo, Japan.
Japanese Heart Journal
|September 1, 1990
Summary
Deoxycorticosterone acetate (DOCA)-salt treatment in rats initially increased plasma atrial natriuretic polypeptide (ANP) levels. However, these levels normalized by day 7, then rose again by day 28, suggesting complex ANP regulation in hypertension.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Renal Physiology
Background:
- Hypertension is a significant cardiovascular risk factor.
- Atrial natriuretic polypeptide (ANP) plays a role in blood pressure regulation.
- The dynamic changes in ANP during hypertension development require further elucidation.
Purpose of the Study:
- To investigate the temporal relationship between deoxycorticosterone acetate (DOCA)-salt induced hypertension and atrial natriuretic polypeptide (ANP) levels.
- To examine changes in both plasma and cardiac ANP concentrations over time.
Main Methods:
- Rats were administered DOCA and sodium chloride to induce hypertension.
- Plasma and cardiac immunoreactive ANP (ir-ANP) levels were measured at 1, 7, and 28 days post-treatment.
- Systolic blood pressure was monitored throughout the study.
Main Results:
- DOCA-salt rats exhibited elevated systolic blood pressure starting from day 7, reaching 191 +/- 7 mmHg by day 28.
- Plasma ir-ANP levels increased at day 1, accompanied by decreased cardiac ir-ANP.
- By day 7, both plasma and cardiac ir-ANP levels returned to control levels. At day 28, plasma ir-ANP was elevated, while cardiac ir-ANP remained comparable to controls.
Conclusions:
- Plasma ANP concentrations undergo time-dependent alterations during the development of DOCA-salt hypertension.
- Elevated plasma ANP levels in later stages of hypertension do not necessarily correlate with reduced cardiac ANP content.