Cholesteryl ester transfer protein: the controversial relation to atherosclerosis and emerging new biological roles
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Updated: Jun 2, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Helena C F Oliveira1, Eliana C de Faria
1Department of Physiology and Biophysics, State University of Campinas, Campinas, SP, Brazil. ho98@unicamp.br
Abstract:
Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity.
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