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Published on: June 30, 2018
Microalbuminuria in normal Korean children.
Byung Ok Kwak1, Sang Taek Lee, Sochung Chung
1Department of Pediatrics, School of Medicine, Konkuk University, Gwangjin-gu, Seoul 143-729, Korea. kimkyo@kuh.ac.kr
Yonsei Medical Journal
|April 14, 2011
Summary
The spot urine microalbumin/creatinine ratio in healthy Korean children decreases with age. This finding helps establish pediatric reference ranges for early detection of kidney and heart conditions.
Area of Science:
- Pediatric Nephrology
- Clinical Biochemistry
Background:
- Microalbuminuria predicts clinical nephropathy and cardiomyopathy.
- Limited data exists on microalbuminuria incidence and reference ranges in healthy children.
Purpose of the Study:
- Establish reference range for spot urine microalbumin/creatinine ratio in Korean children.
- Investigate age-related trends of this ratio in a pediatric population.
Main Methods:
- Studied 352 healthy Korean children (July 2007-March 2010).
- Collected data on height, weight, serum creatinine, spot urine microalbumin/creatinine ratio, and GFR.
- Analyzed data using ANOVA, regression, and Pearson's correlation across 5 age groups.
Main Results:
- Spot urine microalbumin/creatinine ratio significantly decreased with age across all pediatric groups.
- The ratio showed correlations with age, anthropometric measures (height, weight, BMI, BSA), and GFR.
- Specific 2SD ranges were established for each age bracket.
Conclusions:
- Spot urine microalbumin/creatinine ratio declines with age in healthy Korean children.
- This ratio can inform reference ranges and cutoff values for pediatric populations.
- Potential utility in predicting nephropathy and cardiomyopathy in children.
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