The effects of various cleaning and sterilization processes on allograft bone incorporation

Although bone allografts have a long history of safe and effective clinical use, there is great variability in tissue processing and sterilization processes. Chemical and gamma radiation sterilization are commonly performed on allografts, and numerous animal and clinical studies have examined their integration into host bone. The objective of this literature review was to assess the effects of various cleaning and sterilization processes on the incorporation of allograft bone.