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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
Dendritic cell control of tolerogenic responses
Santhakumar Manicassamy1, Bali Pulendran
1Emory Vaccine Center, Yerkes National Primate Research Center, Department of Pathology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Immunological Reviews
|April 15, 2011
Summary
The immune system balances pathogen defense with self-tolerance. Dendritic cells (DCs) and their innate receptors are key to programming this tolerance through cellular interactions and microenvironments.
Area of Science:
- Immunology
- Innate Immunity
- Immunological Tolerance
Background:
- The immune system must distinguish between pathogens and self/commensal antigens.
- Dendritic cells (DCs) are crucial innate immune cells involved in orchestrating immune responses.
- Maintaining immunological tolerance is vital for preventing autoimmunity and controlling responses to commensals and food.
Purpose of the Study:
- To review emerging studies on the innate control of immunological tolerance.
- To highlight the role of dendritic cells (DCs), their receptors, and signaling pathways in programming tolerance.
- To emphasize the influence of cellular interactions and microenvironments on tolerogenic DCs.
Main Methods:
- Review of existing scientific literature.
- Analysis of studies focusing on innate immune receptors and signaling in DCs.
- Examination of research on cellular interactions and microenvironmental factors influencing DC function.
Main Results:
- Innate immune system, particularly DCs, plays a fundamental role in immunological tolerance.
- Specific innate receptors and signaling pathways program DCs towards a tolerogenic state.
- Cellular interactions and the microenvironment significantly influence the programming of tolerogenic DCs.
Conclusions:
- Innate control of tolerogenic responses can be understood through hierarchical organization.
- DCs, their receptors, signaling networks, and interactions represent different levels of this hierarchy.
- Understanding these hierarchies is crucial for comprehending immune system balance.
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