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Related Experiment Video

Updated: Jun 2, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Maxillary sinus augmentation with microstructured tricalcium phosphate ceramic in sheep.

R J Klijn1, J W M Hoekstra, J J J P Van Den Beucken

  • 1Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Clinical Oral Implants Research
|April 15, 2011
PubMed
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Microstructured tricalcium phosphate (MSTCP) particles show promise for maxillary sinus floor augmentation. These osteoinductive particles support bone formation and integrate well in sheep, indicating suitability for surgical applications.

Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Regenerative Medicine

Background:

  • Maxillary sinus floor augmentation is a critical procedure in implant dentistry.
  • Bone substitutes are essential for successful sinus lift outcomes.
  • Evaluating novel biomaterials is crucial for improving surgical predictability.

Purpose of the Study:

  • To assess the biological performance of osteoinductive microstructured tricalcium phosphate (MSTCP) particles.
  • To evaluate MSTCP's efficacy in maxillary sinus floor augmentation surgery.
  • To investigate bone regeneration and material integration in a sheep model.

Main Methods:

  • Maxillary sinus floor augmentation using MSTCP particles in eight Swifter sheep.
  • Unilateral augmentation of the sinus floor in each animal.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Last Updated: Jun 2, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

  • Post-implantation evaluation at 12 weeks using Computed Tomography (CT) imaging and histological analyses.

    • Main Results:

    • MSTCP particles served as a scaffold, promoting cell ingrowth and new bone formation.
    • Significant bone height increase of 6 mm and mean total bone volume of 43% were observed.
    • Histological and CT analyses confirmed successful integration and significant degradation of MSTCP particles.

    Conclusions:

    • Microstructured tricalcium phosphate (MSTCP) particles demonstrate excellent osteoinductive properties.
    • MSTCP is a suitable bone substitute material for maxillary sinus floor augmentation.
    • The study supports the use of MSTCP in reconstructive surgery.