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Related Experiment Video

Updated: Jun 2, 2026

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

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Postnatal brain development: structural imaging of dynamic neurodevelopmental processes.

Terry L Jernigan¹, William F C Baaré, Joan Stiles

¹Department of Cognitive Science and Center for Human Development, University of California, San Diego, CA, USA. tjernigan@ucsd.edu

Progress in Brain Research

|April 15, 2011

Summary

This summary is machine-generated.

Brain development in children involves intricate changes in neural structures and their environment interactions. This review examines age-related brain maturation and its link to behavioral development, considering various influencing factors.

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Area of Science:

Neuroscience
Developmental Psychology
Pediatrics

Background:

Childhood brain development involves significant structural and functional maturation of neural pathways.
Behavioral development is a dynamic interplay between genetic predispositions and environmental influences.
This developmental process spans from gestation through early adulthood.

Purpose of the Study:

To review age-related brain maturational changes in children and adolescents using structural imaging.
To explore the association between these neurodevelopmental changes and behavioral differences.
To discuss factors influencing brain-behavior associations in pediatric populations.

Main Methods:

Review of studies employing structural neuroimaging techniques.
Special focus on diffusion weighted imaging (DWI) for assessing white matter development.
Integration of findings from studies linking brain structure to behavioral outcomes.

Main Results:

Documented age-related changes in brain fiber tracts and cortical/subcortical structures.
Identified correlations between neurodevelopmental trajectories and behavioral variations.
Evidence suggests genetic, environmental, and hormonal factors mediate brain-behavior links.

Conclusions:

Individual trajectories of biological brain development and behavioral development are not yet fully understood.
Further longitudinal research is needed to map variability in neural and behavioral development.
Understanding these complex interactions is crucial for pediatric neuroscience.