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Published on: April 1, 2018
Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder
1Psychiatric Neuroscience Program, MGH–East, CNY2614, Building 149, Thirteenth Street, Charlestown, Massachusetts 02129, USA. geo@nmr.mgh.harvard.edu
Neuroimaging reveals brain abnormalities in attention-deficit/hyperactivity disorder (ADHD), particularly hypofunction in the cingulo-frontal-parietal network. This network is crucial for cognitive functions and interacts with other brain systems implicated in ADHD.
Area of Science:
- Neuroscience
- Neuroimaging
- Psychiatry
Background:
- Attention-deficit/hyperactivity disorder (ADHD) is associated with brain abnormalities.
- Neuroimaging studies consistently identify dysfunction in specific brain networks in individuals with ADHD.
Purpose of the Study:
- To highlight neuroimaging findings related to the cingulo-frontal-parietal network in ADHD.
- To integrate these findings with other aspects of ADHD neurobiology.
Main Methods:
- Review of functional and structural neuroimaging studies in ADHD.
- Focus on the cingulo-frontal-parietal cognitive-attention network.
Main Results:
- Consistent observation of hypofunction in the cingulo-frontal-parietal network across studies.
- Identification of this network's role in cognitive/attention, motor, and reward systems relevant to ADHD.
- Demonstration of interactions between this network and other implicated brain circuits, like the default mode network.
Conclusions:
- Dysfunction in the cingulo-frontal-parietal network is a key feature of ADHD neuropathophysiology.
- Understanding this network's role is vital for elucidating the neurobiology of ADHD.
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